Hamid Karzai is on his way to Camp David for a summit with his US counterpart, George Bush, to discuss issues from the "war on terror" to booming opium production.
South Korea has said it hoped Sunday's meeting between the two presidents could break the deadlock in negotiations for the release of 21 aid workers held hostage by the Taliban.
But the continuing unrest in the country is likely to top the agenda.
Violence in Afghanistan is now at its worst level since 2001 and the rising number of civilian deaths has inflamed public opinion, increased hostilities to foreign troops and further strained Karzai's credibility.
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